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Food and Drug Administrations (FDA) PMTA roundtable on February 10, small manufacturers of electronic nicotine delivery systems (ENDS) questioned the cost, feasibility, and predictability of pharmacokinetic (PK) studies used to assess abuse liability, while FDA officials emphasized that addiction potential remains a necessary component of the agencys determination of whether a product is appropriate for the protection of public health (APPH)

have estimated that the risk of e-cigarettes is much lower than that of combustible tobacco, but not negligible. In the United States, however, public perceptions of the toxicity of nicotine are much higher than warranted, possibly inspired by sensationalized reporting about e-cigarette use, Schroeder wrote

Nicotine Addiction

After some discussion of brand promotion, I brought the conversation around to the issue of smoking and health